hamartia
The tragic flaw of the protagonist in a literary tragedy.
uncountable
Creon's main hamartia was his excessive pride.
Sin.
uncountable
As a consequence of the primeval peripety, the Adamic fall narrated in Genesis 3, they have all inherited the catastrophic and tragic hamartia, as it were, of original sin, the engrained powerlessness of the soul to will the good, much less to do it, along with the deep disorientation of the soul's root desire.
A focal malformation consisting of disorganized arrangement of tissue types.
uncountable
Where it comes from
From Ancient Greek ἁμαρτία (hamartía, “tragic failure, sinful nature”), from the verb ἁμαρτάνω (hamartánō, “to miss the mark”).
Adapted from the Wiktionary entry hamartia (CC BY-SA 4.0).