foundress
A female founder (“one who founds or establishes”).
dated
But whether he departed without the French kings conſent or diſaſſent, he deceiued in his expectacion, and in maner in diſpaire, retourned againe to the Lady Margaret his firſt fooliſh foundreſſe.
A female animal which establishes a colony.
[T]he comparison of multiple inseminations and multiple foundress associations showed that the number of foundresses, a component of migration structure, affects the potential for social evolution more strongly than the number of inseminations per foundress, a component of the mating structure.
Where it comes from
From Middle English founderess, founderesse, foundress (“female founder or builder of a city; female founder or benefactor of a religious house; (figuratively) female inventor or originator; (figuratively) a source”) [and other forms]; from founder, foundere, foundour (“founder or builder of a building, city, country, etc.; builder or endower of a church, college, monastery, etc.; benefactor or patron of such an institution; charter member of a guild; first head of a religious organization; inventor, originator; (figuratively) earliest of a class of people; (figuratively) a source”) + -esse (“suffix forming female forms of words”).
Adapted from the Wiktionary entry foundress (CC BY-SA 4.0).