defatigate
To tire or make weary.
rare
I must say there is something to be said, don't you agree darling, and I rather hope they'll internationalize the cosmic wireless and save us from some of this defatigating news.
Where it comes from
The adjective is first attested circa 1480, in Middle english; borrowed from Latin dēfatīgātus, perfect passive participle of dēfatīgō, see -ate (adjective-forming suffix) and -ate (verb-forming suffix).
Adapted from the Wiktionary entry defatigate (CC BY-SA 4.0).